Single-cell 3D imaging technologies: uncovering biology cell by cell!

Optical – Technique in Focus
16:25 – 17:00 | Tuesday 16 Feb 2020


Anne Rios and her team use and develop advanced 3D imaging technologies to gain insight into cancer progression, predict treatment outcome and contribute to curative solutions with minimal health impacts for patients. She will present a novel methodology which combines advanced 3D imaging with complex human co-culture models of immune cells with patient-derived tumor organoids (3D cellular structures which recapitulates important tumor characteristics). This provide a state-of-the-arts platform that allows not only to improve our limited understanding of the interaction of engineered Tcells with tumor tissue, but also reveal their specific behavior signatures that relate to tumor targeting and killing..


Dr Anne Rios

Dr Anne Rios

Junior Principal Investigator, Princess Máxima Center for Pediatric Oncology

Dr. Anne Rios received her PhD in 2011, during which she identified a novel developmental scenario for stem cell fate decisions. Her PhD started in her hometown in France at the Institute of Marseille Luminy in Marseille, but later continued at the Australian Regenerative Medicine Institute in Melbourne, Australia. She stayed in Melbourne for her postdoctoral fellowship at the Walter and Eliza Hall Institute of Medical Research. Here, she developed a novel 3D imaging technology that enabled visualization of intact tissue at single-cell resolution, powerful for studying organ development and cancer. In 2017, she joined the Princess Máxima Center for Pediatric Oncology as principal investigator and established her ‘DreamTeam’. Together, they advance imaging methodologies and quantification pipelines to tackle major obstacles in cancer treatment. In addition, she heads the Princess Máxima Imaging Center to provide access to a wide range of imaging modalities and share the expertise from her team with the scientific community. Besides her research goals, she is highly passionate about artistic visualizations of microscopic images to engage the public and inspire the future generation of scientists.